Manuel Grez Selected Research

NADPH Oxidases (NAD(P)H oxidase)

1/2018	Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease.
1/2014	Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox).
1/2011	Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.
5/2003	Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker.

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Manuel Grez Research Topics

Disease

9	Neoplasms (Cancer) 01/2021 - 05/2010
9	Chronic Granulomatous Disease 01/2018 - 08/2002
7	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019 - 03/2007
5	Leukemia 01/2018 - 03/2007
4	Infections 01/2020 - 01/2002
3	Vesicular Stomatitis 01/2015 - 05/2002
3	Genetic Translocation (Chromosomal Translocation) 01/2013 - 07/2010
2	Gallbladder Neoplasms (Gallbladder Cancer) 04/2017 - 10/2015
2	Inflammation (Inflammations) 01/2016 - 01/2016
2	Hemophilia A (Haemophilia) 01/2012 - 12/2003
1	Virus Diseases (Viral Diseases) 01/2021
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2015
1	monosomy Chromosome 7 01/2015
1	Neuralgia (Stump Neuralgia) 03/2014
1	Pain (Aches) 03/2014
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 02/2014
1	Mycoses (Diseases, Fungus) 01/2014
1	Hematologic Diseases (Blood Diseases) 01/2014
1	Glioma (Gliomas) 06/2010
1	Adenocarcinoma 05/2010
1	Hematologic Neoplasms (Hematological Malignancy) 04/2010
1	Graft vs Host Disease (Graft-Versus-Host Disease) 04/2010
1	Allergic Contact Dermatitis 03/2010
1	Contact Dermatitis (Eczema, Contact) 03/2010
1	Sepsis (Septicemia) 02/2010
1	Inborn Genetic Diseases (Disease, Hereditary) 08/2002

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 01/2019 - 05/2002
5	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 01/2014 - 08/2002
4	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2018 - 05/2003
2	NADP (NADPH)IBA 01/2016 - 01/2011
2	Chimeric Antigen ReceptorsIBA 02/2015 - 01/2015
2	AntigensIBA 02/2015 - 01/2015
2	InterleukinsIBA 03/2014 - 03/2010
1	PeptidomimeticsIBA 01/2018
1	RiboswitchIBA 01/2018
1	Niacinamide (Nicotinamide)FDA LinkGeneric 01/2018
1	Phosphates (Orthophosphate)IBA 01/2018
1	tanespimycin (17AAG)IBA 04/2017
1	geldanamycinIBA 04/2017
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 01/2016
1	Oxidoreductases (Dehydrogenase)IBA 01/2016
1	Transcription Activator-Like Effector NucleasesIBA 11/2015
1	Sirolimus (Rapamycin)FDA Link 10/2015
1	WYE-354IBA 10/2015
1	vesicular stomatitis virus G proteinIBA 01/2015
1	Surface Antigens (Surface Antigen)IBA 01/2015
1	Antigen Receptors (Antigen Receptor)IBA 01/2015
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2015
1	Cetuximab (Erbitux)FDA Link 06/2014
1	EpitopesIBA 06/2014
1	LigandsIBA 06/2014
1	Doxycycline (Periostat)FDA LinkGeneric 06/2014
1	ErbB Receptors (EGF Receptor)IBA 06/2014
1	Immunoglobulin FragmentsIBA 06/2014
1	Cyclooxygenase InhibitorsIBA 03/2014
1	Epoprostenol ReceptorsIBA 03/2014
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 03/2014
1	Epoprostenol (Prostacyclin)FDA LinkGeneric 03/2014
1	Meloxicam (Mobic)FDA LinkGeneric 03/2014
1	Dinoprostone (PGE2)FDA Link 02/2014
1	Peptides (Polypeptides)IBA 01/2013
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 08/2012
1	CytokinesIBA 08/2012
1	Factor IX (Coagulation Factor IX)FDA LinkGeneric 01/2012
1	Transcription Factors (Transcription Factor)IBA 09/2010
1	Progesterone Receptors (Progesterone Receptor)IBA 05/2010
1	Estrogens (Estrogen)FDA Link 05/2010
1	Phenobarbital (Luminal)FDA Link 05/2010
1	Interleukin-10 (Interleukin 10)IBA 03/2010
1	HaptensIBA 03/2010
1	GTP-Binding Proteins (G-Protein)IBA 08/2008
1	Factor VIII (Coagulation Factor VIII)IBA 12/2003
1	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 05/2003
1	AnionsIBA 01/2002

Therapy/Procedure

6	Therapeutics 01/2018 - 06/2007
4	Transplantation 07/2010 - 02/2010
3	Drug Therapy (Chemotherapy) 01/2021 - 10/2015
2	Radiotherapy 04/2017 - 10/2015
1	Antibiotic Prophylaxis 01/2020
1	Immunotherapy 02/2015
1	Hematopoietic Stem Cell Transplantation 01/2015
1	Intravenous Injections 06/2010